One child died following a major accident on the city's South side. At least two other children were taken by AirLife to University Hospital in unknown condition.
The wreck happened on Interstate 35 near Shepherd Road, around 4:30 p.m. on Wednesday.
According to police, the driver of a black SUV was being monitored in connection with a possible drug transaction on Morin Road near Highway 16 and Loop 1604.
"They observed as several vehicles were loaded with large amounts of marijuana and departed the location," said Sgt. Javier Salazar, with the San Antonio Police Department. "What they were doing is stopping the vehicles as they were leaving and each traffic stop resulting in several hundred pounds of marijuana in each vehicle."
Police said the driver fled, then later made a U-turn in an attempt to ram the police vehicle in pursuit.
"The suspect vehicle actually at one point did a U-turn and turned on the officer in the marked unit," said Salazar. "He actually tried to ram her head-on."
The officer was able to avoid the collision, but the suspect in the SUV struck a station wagon, sending it rolling.
Police said four young children, and their parents were inside the station wagon.
Veronica Morales, a witness on the scene, said when she saw the accident she knew she had to help.
"I saw the poor babies," said Morales. "Oh. My goodness. It's something I wish I wouldn't have seen, but God put me there for a reason to help this poor family out."
Police said all the men who were involved in the bust face felony drug charges.
However, the suspect who slammed into the car will also face charges of evading arrest and manslaughter.