May 9, 2000 - Endorses George W. Bush for president.
2002 - "Worth the Fighting for: A Memoir," is published.
November 2, 2004 - Is re-elected to the Senate for a fourth term.
February 28, 2007 - Appears on the "Late Show with David Letterman" and confirms that he will seek the Republican presidential nomination.
April 25, 2007 - While in New Hampshire, McCain announces he is running for president.
August 29, 2008 - Announced that he has selected Governor Sarah Palin of Alaska to be his vice presidential running mate.
September 4, 2008 - Accepts the Republican nomination for president at the Republican National Convention in St. Paul, Minnesota.
November 4, 2008 - Loses the presidential election to Senator Barack Obama.
November 2, 2010 - Is re-elected to the Senate for a fifth term.
August 29, 2012 - Speaks at the 2012 Republican National Convention in Tampa, Florida, on his 76th birthday.
May 27, 2013 - Meets with rebels in Syria, making him the highest ranking elected official from the United States to visit since the conflict began in March 2011.
August 5, 2013 - At President Obama's request, U.S. Senators McCain and Lindsey Graham arrive in Cairo to meet with Egyptian interim leaders and separately, with the Muslim Brotherhood leadership.