November 2006 - Has a cancerous tumor removed from her right shin.
August 2007 - The Laura W. Bush Institute for Women's Health is founded as part of the Texas Tech University Health Sciences Center.
October 21, 2007 - Arrives in the United Arab Emirates to begin a four-day tour around the Middle East to raise breast cancer awareness.
February 16, 2008 - Begins a five-day, five nation tour of Africa with the president. They visit Benin, Rwanda, Tanzania, Ghana, and Liberia.
June 2008 - Tours Afghanistan.
August 2008 - In Thailand, she meets with refugees from Myanmar. Later attends the summer Olympics with the president and former President Bush.
September 1, 2008 -- Is a speaker at the Republican National Convention.
December 19, 2008 - An official portrait of Mrs. Bush is unveiled at the Smithsonian Institution's National Portrait Gallery.
May 4, 2010 - Her autobiography, "Spoken From the Heart," is released.
May 16, 2010 - Comes out in support of legalizing same-sex marriage and abortion remaining legal on the Larry King Live show.
April 13, 2013 - Becomes a grandmother for the first time after her daughter, Jenna, and her husband, Henry Hager, have a baby girl, Margaret Laura "Mila" Hager.