One child died following a major accident on the city's South side.
At least two other children were taken by AirLife to University Hospital in unknown condition.
The wreck occurred on Interstate 35 near Shepherd Road around 4:30 p.m. on Wednesday.
According to police, the driver of a black SUV was being monitored in connection with a possible drug transaction near Highway 16 and Loop 1604.
Police said the driver fled, then later made a U-turn in an attempt to ram the police vehicle in pursuit. Instead, the SUV struck a station wagon, sending it rolling.
Police said the children were inside the station wagon.