A stretch of Highway 87 in Gonzales County could be closed until at least 4 a.m. while crews work to right an overturned tanker and clean up leaking gasoline.
The accident happened Friday night between Nixon and Smiley - about 50 miles east of San Antonio.
The truck holds 8,000 gallons of gasoline. That cargo is leaking. Crews are working carefully to clean up the scene.
At least one person was hurt.