Clinton was considered a favorite in 2008, but Obama, who served with her in the Senate, got an early jump in the primaries. Clinton was unable to capture the momentum in a fierce political battle.
Despite the rugged campaign, Obama chose Clinton for his Cabinet and she embraced the role.
In a joint interview with CBS that aired on Sunday, Obama said that he believes Clinton's legacy will rank among the best.
"It has been a great collaboration over the last four years," Obama said. "I'm going to miss her."