Police said Jerry Moreno, 33, was fatally shot in front of his Southeast Side home early Wednesday morning.
San Antonio police responded to a call for shots fired around 2 a.m. in the 4200 block of Apple Tree Street near the intersection of South W.W. White and East Southcross.
"When officers arrived on the scene, the victim was lying face down in the front yard. It appeared he had several -- or multiple -- gunshot wounds to his head," said San Antonio police Officer Roger Zuniga.
Witnesses told San Antonio police they heard the gunshots and then saw two men flee the scene in a white four-door car.
Police do not think the gunmen were strangers to Moreno.
"The suspects went to the location, and contacted the victim, and the victim went outside with these two individuals, and it appeared that he knew them," Zuniga said.
A witness told police that Moreno suddenly turned around and tried to run toward the house, but that is when the men opened fire.
One of the shooters is described as 30 to 40 years old, about 5 feet, 8 inches tall and weighing about 220 pounds. He was wearing a dark hoodie and dark jeans.
The other man is believed to be in his early 20s, 5 feet, 5 inches tall and weighing about 140 pounds. He was wearing a grey hoodie and light-colored jeans.
Police initially thought the men were involved in a wreck at Hot Wells and Interstate 37. They later determined the white car involved in that crash was not connected to the murder.