"We're working very hard to reduce injuries, but unfortunately you can never totally reduce risk," the race course's managing director, John Baker, told CNN.
"Horse deaths are part-and-parcel of life in general. A horse can get injured just as easily exercising in a field."
Baker stressed how well cared-for the thoroughbreds were by dedicated teams of trainers, stablehands and jockeys.
Similarly, jockey Katie Walsh, who finished third on Seabass last year, told London's Radio Times this week that the horses were looked-after "better than some children".
Asked if he thought the public had been put off by nine horse deaths in the last 10 years, Baker pointed to the huge numbers still watching the race every year.
"Eleven million people watched it on the BBC last year -- more than the football, which is supposed to be our national sport," he said. "It suggests that the Grand National remains extremely popular and there's no sign of that decreasing."