Dead people's nerves help the living


BACKGROUND:   There are three types of nerves in the body, autonomic nerves, motor nerves, and sensory nerves.  Autonomic nerves control the involuntary activities of the body, including blood pressure, heart rate, and digestion.  Motor nerves control actions and movements by transferring information from the brain and spinal cord to the muscles.  Sensory nerves relay information from the skin and muscles back to the spinal cord and brain.  The information is then processed to let you feel pain and other sensations.  There are more than 100 different types of nerve damage.  (Source:  www.webmd.com)


SYMPTOMS:  Nerve damage can cause a wide range of symptoms.  Symptoms will depend on the location and type of nerves that are affected.  Damage could occur to nerves in the spinal cord and brain.  It can also occur in peripheral nerves, which are located throughout the rest of the body. 

·         Autonomic nerve damage can cause sexual dysfunction, dry eyes and mouth, bladder dysfunction, constipation, too much sweating or too little sweating, lightheadedness, and inability to sense chest pain.

·         Damage to motor nerves can cause muscle atrophy, twitching, paralysis, and weakness.

·         Sensory nerve damage can cause sensitivity, pain, numbness, prickling or tingling, burning, and problems with positional awareness.  (Source: www.webmd.com)


TREATMENT:  In many cases, nerve damage cannot be cured.  Usually the first goal of treatment is to address the underlying condition that is causing the nerve damage.  This could mean: medications to treat autoimmune conditions, physical therapy or surgery to address compression or trauma to nerves, correcting nutritional deficiencies, regulating blood sugar levels for people with diabetes, or changing medications when drugs are causing the nerve damage.  Medications can also be aimed at minimizing the nerve pain.  (Source: www.webmd.com


NEW TECHNOLOGY:  Traditional methods of facial nerve reconstruction include autologous and cadaveric grafting; both can lead to patient morbidity.  Autologous nerve grafts are the "gold standard" for superior regenerative capability, but are limited by the length and potential.  Allogenic grafts from donors or cadavers have shown efficiency, but can require immunosuppression.  (Source:  http://www.ncbi.nlm.nih.gov/pubmed/21225804)  AVANCE Nerve Graft is peripheral nerve allograft for the reconstruction of peripheral nerve discontinuities (severed nerve gaps) in order to guide and structurally support axonal regeneration across a nerve gap caused by traumatic injury or surgical intervention.  It is a sterile extracellular matrix that is processed from human peripheral nerve tissue.  The AVANCE Nerve Graft was developed by AxoGen by following the princlipe that the human body created the optimal nerve structure.  The AVANCE Nerve Graft provides natural nerve structure of an autograft and the ease and availability of off-the-shelf products.  AVANCE Nerve Graft is made up of bundles of small diameter tubes that are held together by an outer tube.   It has been processed to remove noncellular and cellular factors like fat, cells, blood, axonal debris, and chondroitin sulfate proteoglycans while also preserving the three dimensional scaffold and structure of the peripheral nerve.  It is offered in a variety of sizes with lengths between 15mm and 70mm and diameters up to 5mm, allowing the surgeon to choose the correct length for the relevant nerve gap.  (Source: http://www.axogeninc.com/nerveGraft.html)


Bottom of Form



John R. Zuniga, DMD, MS, PhD

Robert V. Walker DDS Chair in Oral and Maxillofacial Surgery

Professor of Surgery

University of Texas Southwestern Medical Center in Dallas

(214) 648-3527