Brock Purdy threw three touchdown passes in his return from a toe injury, Christian McCaffrey had two rushing touchdowns and a receiving score, and the San Francisco 49ers beat the sloppy Arizona Cardinals 41-22.

Josh Allen threw a go-ahead, 5-yard touchdown pass to Stefon Diggs late in the first half and Buffalo beat the Cleveland Browns 31-23 after the NFL moved the Bills’ home game to Detroit due to several feet of snow blanketing western New York.

Daniel Jones is active and is expected to start at quarterback for the New York Giants against the Arizona Cardinals on Sunday. After missing last week’s game with a hamstring injury, Jones practiced fully for the first time on Friday. Jaguars: QB Jake Luton, CB Luq Barcoo, LB Kamalei Correa, LB Quincy Williams, C Brandon Linder, TE Tyler Davis, DE Reggie Gilbert. Giants: WR Dante Pettis, CB Darnay Holmes (knee), ILB T.J. Brunson, OT Kyle Murphy, OT Jackson Barton, DE R.J. McIntosh. Buccaneers: DL Khalil Davis, CB Jamel Dean, RB Leonard Fournette, QB Ryan Griffin, TE Tanner Hudson, DL Jeremiah Ledbetter.

Indianapolis Colts middle linebacker Anthony Walker (54) celebrates with teammates after he recovered a fumble by Houston Texans quarterback Deshaun Watson during the second half of an NFL football game Sunday, Dec. 6, 2020, in Houston. (AP Photo/Eric Christian Smith)HOUSTON – With their offense sputtering in the second half Sunday, the Indianapolis Colts turned to their defense to seal a win over the Houston Texans. Philip Rivers threw two touchdown passes in the first half and the defense dominated after that, lifting the Colts to the 26-20 victory. Their offense didn't score after that, but the defense held Houston (4-8) scoreless in the second half and Justin Houston added a safety with a sack of Watson in the end zone. With Sunday's shutout in the second half, the Colts are allowing an average of 7.33 points in the second half of games this season.

The Houston Texans have struggled to run the ball all season long. The Texans finished with season lows of 153 yards passing and 243 total yards in their 10-7 loss to the Browns. Deshaun Watson, who entered Sunday averaging 280.8 yards passing, acknowledged that the weather conditions made things difficult on him. The Texans entered the game ranked 31st in the NFL with an average of 87.6 yards rushing per game. As bad as the Texans played offensively, they were in the game at the very end.