Shares fell in Tokyo and Sydney on Friday after stocks closed nearly flat on Wall Street, though the S&P 500 and the Nasdaq composite still logged record highs.
Most Asian markets were closed to mark the Lunar New Year.
Investors remain cautiously optimistic about prospects for a new round of government aid as the economic recovery seemingly stalls.
The latest U.S. government report on jobless claims reaffirmed that employment remains a weak spot in the economy, even as vaccine distribution ramps up in the hopes of eventually ending the pandemic.
Japan's Nikkei 225 index lost 0.3% to 29,460.56 and the A&P/ASX 200 declined 0.5% to 6,814.90.
Weak economic data are serving to “fog up the glass," Stephen Innes of Axi said in a commentary.
“Global markets continue to trade mixed echoing that somber data view as participation remains muted, suggesting that investors need a bit more cajoling by more all clear economic smoke signal on the horizon before getting back in the saddle," Innes said.
Although another day of choppy trading on Wall Street left the major U.S. stock indexes nearly flat Thursday, the S&P 500 and Nasdaq composite still hit all-time highs.
The S&P 500 rose 0.2% to 3,916.38. Technology stocks led the gainers after two relatively weak days, almost single-handedly outweighing losses by energy stocks, banks and companies that rely on consumer spending.
The yield on 10-year Treasury notes rose to 1.16% from 1.15% late Wednesday after touching 1.20% earlier this week.
Wall Street is still digesting solid corporate earnings and signs of a decline in new virus cases.
The Dow Jones Industrial Average slipped less than 0.1% to 31,430.70 a day after setting a record high. The tech-heavy Nasdaq gained 0.4%, to 14,025.77. Its previous all-time high was Tuesday.
Small company stocks notched gains. The Russell 2000 index added 0.1% to 2,285.32. The index is up 15.7% so far this year, while the S&P 500 is up 4.3%.
Democrats in Congress are working on a potential $1.9 trillion relief package that would include direct payments to people and more jobless aid as unemployment remains stubbornly high.
The number of Americans seeking unemployment benefits fell slightly last week to 793,000. The job market improved somewhat last summer but has slowed since the fall. Nearly 10 million jobs have been lost to the pandemic.
Companies continued reporting mostly solid earnings Thursday, adding to a surprisingly good earnings season. Kraft Heinz climbed 4.9% and Zillow Group jumped 17.8% after beating Wall Street's fourth-quarter profit forecasts.
The pandemic and business shutdowns are still hurting many companies and crimping their financial results. Molson Coors fell 9.1% for the biggest decline in the S&P 500 after its profits fell short of expectations because business shutdowns in Europe hurt sales.
Shares of online dating service operator Bumble soared 63.5% on their first day of trading. And cannabis stocks fell broadly a day after surging amid a buying spree fueled partly by members of the same online forum that hyped GameStop and other beaten-down companies in recent weeks.
Aphria and Tilray, Canadian cannabis companies that agreed to combine in December, fell 35.8% and 49.7%, respectively. So far this year, Aphria has more than doubled, while Tilray has nearly quadrupled in value. Sundial Growers fared better, recovering from an early slide to gain 3.1%. It's price has increased more than six-fold this year.
Shares of Mastercard rose 2.6% after the payment processing company said it would start integrating cyber currencies into its payment network, allowing people to potentially transfer currencies like Bitcoin from customer to merchant. Bitcoin also rose on the announcement, gaining more than 4%, according to the online currency brokerage Coinbase.
In other trading, U.S. benchmark crude lost 47 cents to $57.77 per barrel in electronic trading on the New York Mercantile Exchange. It gave up 44 cents overnight to $58.24. Brent crude, the international standard, shed 43 cents to $60.71 per barrel.
The U.S. dollar rose to 104.82 Japanese yen from 104.75 yen. The euro slipped to $1.2120 from $1.2131.
AP Business writers Damian J. Troise and Alex Veiga contributed.