The EU and Britain disagree notably on regulations for businesses and for the fishing industry in particular, with the U.K. adamantly opposed to EU demands for long-term access to British waters.
Last week, the EU and the U.K. agreed to intensify their negotiations following another inconclusive round of discussions.
The U.K. left the political institutions of the EU on Jan. 31 but remains inside the EUs tariff-free economic zone until the end of the year.
European Council President Charles Michel and David Sassoli, the president of the European Parliament, will attend Monday's meeting alongside von der Leyen.
Britains Michael Gove, the minister in charge of Brexit preparations, and David Frost, the U.K chief negotiator, are set to assist Johnson.