The Texas Department of Transportation has reported a major crash on the southbound lanes of Highway 281 near St. Mary’s Street on Friday, April 17, 2026. (KSAT)
SAN ANTONIO – A woman was hit and killed by a vehicle on Friday morning along the southbound lanes of U.S. Highway 281 on the North Side.
Nancy Villarreal, 51, was pronounced dead at the scene, according to the Bexar County Medical Examiner’s office, after a crash just after 4:15 a.m. on the St. Mary’s Street ramp onto U.S. Highway 281 southbound.