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| Visitor Team | Visitor Score | Home Team | Home Score | Start Date |
|---|---|---|---|---|
| Boerne | 14 | Harlandale | 12 | 9/19/2019 |
| 5-Wagner | 35 | Lanier | 0 | 9/19/2019 |
| 6-O'Connor | 23 | John Jay | 12 | 9/19/2019 |
| Clark | 0 | 2-Brandeis | 42 | 9/19/2019 |
| Seguin | 44 | Austin NE Early College | 6 | 9/20/2019 |
| Austin Brentwood Christian | 41 | TMI | 7 | 9/20/2019 |
| Central Catholic | 0 | Austin Regents | 29 | 9/20/2019 |
| Uvalde | 7 | Memorial | 12 | 9/20/2019 |
| Kennedy | 0 | Alamo Heights | 58 | 9/20/2019 |
| Lockhart | 17 | Medina Valley | 7 | 9/20/2019 |
| Laredo United South | 42 | Southwest | 35 | 9/20/2019 |
| Highlands | 12 | Jefferson | 27 | 9/20/2019 |
| Edison | 0 | Veterans Memorial | 59 | 9/20/2019 |
| Brackenridge | 28 | Burbank | 13 | 9/20/2019 |
| Holmes | 0 | Warren | 28 | 9/20/2019 |
| 10-Roosevelt | 27 | MacArthur | 16 | 9/20/2019 |
| Reagan | 31 | Johnson | 38 | 9/20/2019 |
| East Central | 42 | San Marcos | 38 | 9/20/2019 |
| 7-Clemens | 15 | Smithson Valley | 7 | 9/20/2019 |
| NB Canyon | 21 | New Braunfels | 47 | 9/20/2019 |
| 1-Judson | 51 | 3-Steele | 48 | 9/20/2019 |
| Eagle Pass | 38 | McCollum | 0 | 9/20/2019 |
| Pearsall | 6 | EP Winn | 29 | 9/20/2019 |
| 8-Champion | 19 | Kerrville Tivy | 24 | 9/20/2019 |
| Southwest Legacy | 16 | Laredo Johnson | 17 | 9/20/2019 |
| Stevens | 34 | Marshall | 7 | 9/20/2019 |
| Poth | 31 | Johnson City | 12 | 9/20/2019 |
| Pleasanton | 41 | Devine | 26 | 9/20/2019 |
| Crystal City | 20 | Laredo Cigarroa | 0 | 9/20/2019 |
| Canyon Lake | 55 | Smithville | 28 | 9/20/2019 |
| Wimberley | 48 | Fredericksburg | 31 | 9/20/2019 |
| La Vernia | 28 | Lampasas | 48 | 9/20/2019 |
| Comfort | 12 | Bandera | 35 | 9/20/2019 |
| Cuero | 20 | Gonzales | 21 | 9/20/2019 |
| Austin Eastside Memorial | 0 | Schertz John Paul II | 42 | 9/20/2019 |
| Navarro | 55 | La Grange | 22 | 9/20/2019 |
| Cotulla | 22 | Carrizo Springs | 18 | 9/20/2019 |
| Hondo | 27 | Marion | 35 | 9/20/2019 |
| Jourdanton | 58 | Natalia | 18 | 9/20/2019 |
| Karnes City | 21 | Three Rivers | 6 | 9/20/2019 |
| Dilley | 15 | Lytle | 35 | 9/20/2019 |
| Nixon-Smiley | 19 | Cole | 41 | 9/20/2019 |
| Randolph | 14 | Blanco | 7 | 9/20/2019 |
| Center Point | 2 | Ingram Moore | 24 | 9/20/2019 |
| Shiner | 52 | El Maton Tidehaven | 0 | 9/20/2019 |
| Stockdale | 7 | Yorktown | 21 | 9/20/2019 |
| Runge | 13 | Kenedy | 57 | 9/20/2019 |
| Charlotte | 45 | St. Gerard | 14 | 9/20/2019 |
| Boerne Geneva | 14 | Falls City | 35 | 9/20/2019 |
| La Pryor | 49 | Sabinal | 0 | 9/20/2019 |
| San Antonio The Winston | 12 | Nueces Canyon | 58 | 9/20/2019 |
| Leakey | 46 | SA The Christian School at Castle Hills | 0 | 9/20/2019 |
| San Marcos Academy | 27 | Brooks Academy | 7 | 9/20/2019 |
| Dallas Bishop Dunne | 23 | Cornerstone | 26 | 9/20/2019 |
| KIPP Sunnside | 8 | St. Anthony | 54 | 9/21/2019 |
| Del Rio | 21 | 9-Harlan | 28 | 9/21/2019 |
| South San | 27 | LEE | 14 | 9/21/2019 |
| Churchill | 21 | Madison | 28 | 9/21/2019 |
| Holy Cross | 14 | 12-Antonian | 19 | 9/21/2019 |
| 4-Brennan | 29 | Taft | 10 | 9/21/2019 |
| Brackett | 22 | D'Hanis | 28 | 9/21/2019 |